KAJIAN SENYAWA HEXOSE DAN MALIC ACID SEBAGAI INHIBITOR PAPAIN LIKE PROTEASE (PLPro) CORONA VIRUS

Papain-like protease is a SARSCOV-2 that functions for ubiquitination in host cells. Caffeine compounds have been widely reported to antioxidant, anti-inflammatory, antidiabetic, and antiobesity activities. However, hexose malic acid coffee rind as potential inhibitors of the papain-like SARSCOV2 not reported. This study investigated PLPro inhibitor agents inhibiting ubiquitination. In silico studies were used identify two by interacting with (PLPro) proteins Molegro virtual Docker 5 program. Next, ligand-protein complex visualization was done discovery studio version 5.0. showed interactions on several active site residues. The inhibition stimulation interferon compound complexes – protein hydrophobic interactions, hydrogen bonds, van der Waals forces, which contributed formation bond energy strong bonds between proteins. this study, it concluded act protein.